Research peptides · Specialized research compounds
KPV
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Product details
Overview
KPV denotes Lys-Pro-Val, a tripeptide corresponding to the C-terminal region of α-MSH. Research examines inflammatory signalling, epithelial barriers, and peptide-delivery systems.
Structure and technical data
Technical data
Format: 10 mg. Reference structure: H-Lys-Pro-Val-OH. The formula represents the tripeptide with free termini, excluding salts and excipients.
- Sequence
- H-Lys-Pro-Val-OH (KPV)
- Molecular formula
- C16H30N4O4
- Reported molecular mass
- 342.43 g/mol
- CAS number
- 67727-97-3
- PubChem CID
- 125672
- Reported synonyms
- MSH (11-13); α-MSH (11-13); ACTH-(11-13)
Reference molecular data.
Research context
The cited publications study PepT1-mediated transport and hydrogels incorporating KPV. Stability, release, and intestinal-barrier markers are evaluated in cell and animal models. Results for an experimental hydrogel do not automatically describe a vial of peptide alone.
Cell entry through PepT1NF-κB, MAPK, and intestinal modelsHydrogels: stability, adhesion, and releaseOral mucositis and multicomponent formulationsBronchial epithelium and evidence type
Cell entry through PepT1
The Gastroenterology study examines KPV transport in intestinal epithelial and immune cells. PepT1 transports di- and tripeptides; its expression affects peptide access to the cellular system. Uptake assays and signalling readouts distinguish transport from the biological response.
NF-κB, MAPK, and intestinal models
Research measures NF-κB and MAPK activation, cytokines, and tissue integrity in cells and mouse colitis models. Other models examine T-cell transfer and melanocortin-receptor involvement. Model differences clarify whether an observation concerns transport, immune responses, or the epithelial barrier.
Hydrogels: stability, adhesion, and release
SH-PGA hydrogel incorporates KPV into a self-cross-linked polymer network. The study measures mechanical properties, stability, and peptide release. A different double-network hydrogel targets adhesion to inflamed mucosa. The matrix contributes to local exposure rather than acting as an inert container.
10.1021/acsbiomaterials.1c00792 10.1016/j.actbio.2022.02.039
Oral mucositis and multicomponent formulations
The mucositis paper uses KPV with a thermosensitive polymer and EGCG, which contributes adhesion and antibacterial activity. A rat model assesses mucosa, feeding, and weight recovery. Properties of the full formulation cannot all be attributed to isolated KPV.
Bronchial epithelium and evidence type
The bronchial-epithelium reference studies inflammatory signals in cultured human cells. Human cells describe culture origin, not a patient trial.
References
- Mechanism of KPV action and a role for MC3R agonists
- Orally Targeted Delivery of Tripeptide KPV
- PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation
- Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats
- A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon
- Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
- In situ mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis
- Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists
Catalog of products presented for research activities. Not for human or veterinary use. This notice does not replace verification of applicable rules.